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Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study.
- Source :
-
Psychiatry research [Psychiatry Res] 2009 Jan 30; Vol. 171 (1), pp. 1-9. Date of Electronic Publication: 2008 Dec 16. - Publication Year :
- 2009
-
Abstract
- A randomized, placebo-controlled study was performed to evaluate whether the onset of the glucose metabolic effects of a selective serotonin reuptake inhibitor (paroxetine) would be accelerated by total sleep deprivation (TSD). Patients were randomly assigned to one of three groups: TSD and paroxetine treatment, TSD and 2 weeks of placebo followed by paroxetine treatment, or 2 weeks of paroxetine treatment. Sixteen elderly depressed patients who met DSM-IV criteria for major depressive disorder and nine age-matched comparison subjects underwent positron emission tomography (PET) studies of cerebral glucose metabolism at baseline, post-TSD (or a normal night's sleep for the paroxetine- only group), post-recovery sleep and 2 weeks post-paroxetine or placebo treatment (patients only). TSD was not consistently associated with a decrease in depressive symptoms between groups nor with decreases in cerebral metabolism in cortical regions that have been associated with rapid and sustained clinical improvement (e.g. anterior cingulate gyrus). The observation of a synergistic antidepressant effect of combined TSD and paroxetine treatment that was observed in a previous "open label" pilot study was not observed in the present randomized study, consistent with lack of a cerebral metabolic effect in brains regions previously shown to be associated with improvement of depressive symptoms.
- Subjects :
- Aged
Cognition Disorders diagnosis
Cognition Disorders epidemiology
Depressive Disorder, Major psychology
Humans
Male
Neuropsychological Tests
Brain anatomy & histology
Brain metabolism
Depressive Disorder, Major drug therapy
Depressive Disorder, Major epidemiology
Glucose metabolism
Magnetic Resonance Imaging
Paroxetine therapeutic use
Positron-Emission Tomography
Selective Serotonin Reuptake Inhibitors therapeutic use
Sleep Deprivation epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 171
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 19087899
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2008.05.001