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[Hypotensive effect of oxatriazolium-5-olate derivative].

Authors :
Artem'eva MM
Postnikov AB
Akinfrieva OV
Daliger IL
Shevelev SA
Medvedev OS
Medvedeva NA
Source :
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2008 Sep-Oct; Vol. 71 (5), pp. 25-7.
Publication Year :
2008

Abstract

Intravenous administration of azasidnon-6 (oxatriazolium-5-olate derivative) induces prolonged dose-dependent decrease in arterial blood pressure in awake Wistar and SHR rats. Hypotensive effects of azasidnon-6 in SHR rats is significantly higher during inhibition of endogenous NO synthesis.

Subjects

Subjects :
Animals
Delayed-Action Preparations pharmacology
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Hypertension metabolism
Male
Nitric Oxide metabolism
Rats
Rats, Inbred SHR
Rats, Wistar
Antihypertensive Agents pharmacology
Blood Pressure drug effects
Hypertension drug therapy
Hypertension physiopathology
Triazoles pharmacology

Details

Language :
Russian
ISSN :
0869-2092
Volume :
71
Issue :
5
Database :
MEDLINE
Journal :
Eksperimental'naia i klinicheskaia farmakologiia
Publication Type :
Academic Journal
Accession number :
19093367

Tools

Authors Abstract Subjects Details