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Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.
- Source :
-
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2009 Jan; Vol. 4 (1), pp. 22-9. - Publication Year :
- 2009
-
Abstract
- Introduction: Although mutation of the epidermal growth factor receptor (EGFR) gene is predictive for the response to EGFR-tyrosine kinase inhibitor, its prognostic impact for patients without EGFR-tyrosine kinase inhibitor treatment remains controversial. We examined for EGFR, KRAS or TP53 mutations in a consecutive large cohort of patients with lung adenocarcinoma, and evaluated their prognostic impact.<br />Methods: We analyzed 397 patients with lung adenocarcinoma who underwent potentially curative pulmonary resection. Total ribonucleic acid was extracted and direct sequencing of each gene was performed after reverse transcription-polymerase chain reaction.<br />Results: We found that 196 patients (49%) had EGFR mutations. Of these, 83 were exon 19 deletions (42%) and 92 were L858R (47%). Univariate analysis showed that patients with EGFR mutations survived for a longer period than those without mutations (p = 0.0046). However, there was no difference in overall survival between the patients with exon 19 deletion and those with L858R (p = 0.4144). Patients with KRAS mutations or TP53 mutations tended to survive for a shorter period (p = 0.2183 and 0.0230, respectively). Multivariate analysis using the Cox proportional hazards model revealed that smoking status (p = 0.0310) and disease stage (p < 0.0001) were independent prognostic factors. However, none of the gene mutations was independent prognostic factors (EGFR, p = 0.3225; KRAS, p = 0.8500; TP53, p = 0.3191).<br />Conclusions: EGFR, KRAS, and TP53 gene mutations were not independently associated with the prognosis for Japanese patients with surgically treated lung adenocarcinoma.
- Subjects :
- Adenocarcinoma secondary
Adenocarcinoma surgery
Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Cell Differentiation
Cohort Studies
Female
Follow-Up Studies
Humans
Lung Neoplasms pathology
Lung Neoplasms surgery
Male
Middle Aged
Molecular Sequence Data
Neoplasm Staging
Prognosis
Proto-Oncogene Proteins p21(ras)
RNA, Messenger genetics
RNA, Messenger metabolism
RNA, Neoplasm genetics
RNA, Neoplasm metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Smoking
Survival Rate
Tumor Suppressor Protein p53 metabolism
Adenocarcinoma genetics
ErbB Receptors genetics
Lung Neoplasms genetics
Mutation genetics
Proto-Oncogene Proteins genetics
Tumor Suppressor Protein p53 genetics
ras Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1556-1380
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 19096302
- Full Text :
- https://doi.org/10.1097/JTO.0b013e3181914111