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Pulmonary hypertension in systemic sclerosis determines cardiac autonomic dysfunction assessed by heart rate turbulence.

Authors :
Bienias P
Ciurzyński M
Korczak D
Jankowski K
Glińska-Wielochowska M
Liszewska-Pfejfer D
Gliński W
Pruszczyk P
Source :
International journal of cardiology [Int J Cardiol] 2010 Jun 11; Vol. 141 (3), pp. 322-5. Date of Electronic Publication: 2008 Dec 20.
Publication Year :
2010

Abstract

There is limited data on heart rate turbulence (HRT) in systemic sclerosis (SSc) patients, potentially threatened with cardiac autonomic dysfunction. We performed 24-hour Holter monitoring for HRT assessment in 45 patients with SSc and 30 healthy controls. Abnormal HRT defined as turbulence onset (TO) >or=0.0% and/or turbulence slope (TS)<or=2.5 ms/RR was found in 19 (42%) of SSc patients while not in controls. HRT was significantly impaired in SSc group, as compared to controls: a median of TO was higher (-0.13 vs. -2.45%, p=0.0001), and a median of TS was lower (6.90 vs. 13.21 ms/RR, p=0.0003), respectively. Multivariate analysis showed that abnormal HRT in SSc was significantly influenced by pulmonary hypertension (PH) (OR 6.1, 1.1-48.6; p=0.049) and older age (OR 1.8, 95%CI 1.1-3.5; p=0.03). In conclusion, HRT assessment indicates a frequent impairment of cardiac autonomic nervous system in SSc patients. Moreover, older age in these patients and especially PH are independent significant predictors of cardiac autonomic dysfunction.<br /> (Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1874-1754
Volume :
141
Issue :
3
Database :
MEDLINE
Journal :
International journal of cardiology
Publication Type :
Editorial & Opinion
Accession number :
19101049
Full Text :
https://doi.org/10.1016/j.ijcard.2008.11.093