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Pulmonary hypertension in systemic sclerosis determines cardiac autonomic dysfunction assessed by heart rate turbulence.
- Source :
-
International journal of cardiology [Int J Cardiol] 2010 Jun 11; Vol. 141 (3), pp. 322-5. Date of Electronic Publication: 2008 Dec 20. - Publication Year :
- 2010
-
Abstract
- There is limited data on heart rate turbulence (HRT) in systemic sclerosis (SSc) patients, potentially threatened with cardiac autonomic dysfunction. We performed 24-hour Holter monitoring for HRT assessment in 45 patients with SSc and 30 healthy controls. Abnormal HRT defined as turbulence onset (TO) >or=0.0% and/or turbulence slope (TS)<or=2.5 ms/RR was found in 19 (42%) of SSc patients while not in controls. HRT was significantly impaired in SSc group, as compared to controls: a median of TO was higher (-0.13 vs. -2.45%, p=0.0001), and a median of TS was lower (6.90 vs. 13.21 ms/RR, p=0.0003), respectively. Multivariate analysis showed that abnormal HRT in SSc was significantly influenced by pulmonary hypertension (PH) (OR 6.1, 1.1-48.6; p=0.049) and older age (OR 1.8, 95%CI 1.1-3.5; p=0.03). In conclusion, HRT assessment indicates a frequent impairment of cardiac autonomic nervous system in SSc patients. Moreover, older age in these patients and especially PH are independent significant predictors of cardiac autonomic dysfunction.<br /> (Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Electrocardiography, Ambulatory
Female
Heart innervation
Heart physiology
Heart Rate
Humans
Male
Middle Aged
Autonomic Nervous System Diseases complications
Autonomic Nervous System Diseases physiopathology
Hypertension, Pulmonary complications
Hypertension, Pulmonary physiopathology
Scleroderma, Systemic complications
Scleroderma, Systemic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 141
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Editorial & Opinion
- Accession number :
- 19101049
- Full Text :
- https://doi.org/10.1016/j.ijcard.2008.11.093