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Suspended moxibustion relieves chronic visceral hyperalgesia via serotonin pathway in the colon.
- Source :
-
Neuroscience letters [Neurosci Lett] 2009 Feb 20; Vol. 451 (2), pp. 144-7. Date of Electronic Publication: 2008 Dec 24. - Publication Year :
- 2009
-
Abstract
- Experiments in rats have shown that chronic visceral hyperalgesia can be relieved by electro-acupuncture, but the efficacy of suspended moxibustion for relieving chronic visceral hyperalgesia is still unclear. The present study aimed to evaluate the effect of suspended moxibustion on rectal sensory thresholds and to analyze its possible mechanisms when treating chronic visceral hypersensitivity rats. Suspended moxibustion was administered once daily to 37-day-old chronic visceral hypersensitivity rats for 7 days. The two acupoints (ST25, bilateral) were simultaneously given suspended moxibustion. Each treatment lasted for 15 min. Rats in treatment of suspended moxibustion was not anesthetized. Untreated chronic visceral hypersensitivity rats and normal rats were used as controls. The abdominal withdrawal reflex was determined during 30-90 min after the first treatment. A 5-cm long segment of distal colon was harvested after seven treatments and 5-hydroxytryptamine concentrations in the colon were assayed by enzyme-linked immunosorbent assay. Abdominal withdrawal reflex scores from the rectus abdominis in response to colorectal distention were increased in rats with chronic visceral hypersensitivity, and the stimulation at strength of 20 mmHg was significantly depressed by suspended moxibustion. Suspended moxibustion increased the pain threshold and restored normal sensitivity by reducing 5-hydroxytryptamine concentrations in the colon of chronic visceral hypersensitivity rats.
- Subjects :
- Animals
Animals, Newborn
Colon innervation
Disease Models, Animal
Down-Regulation physiology
Hyperalgesia metabolism
Irritable Bowel Syndrome metabolism
Irritable Bowel Syndrome physiopathology
Irritable Bowel Syndrome therapy
Male
Nociceptors physiology
Pain Threshold physiology
Rats
Rats, Sprague-Dawley
Reflex physiology
Serotonin analysis
Treatment Outcome
Visceral Afferents metabolism
Colon physiopathology
Hyperalgesia physiopathology
Hyperalgesia therapy
Moxibustion methods
Serotonin metabolism
Visceral Afferents physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 451
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 19114087
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.12.026