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Severe neurologic complication after delayed hemolytic transfusion reaction in 2 children with sickle cell anemia: significant diagnosis and therapeutic challenges.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2008 Dec; Vol. 30 (12), pp. 928-30. - Publication Year :
- 2008
-
Abstract
- Although delayed hemolytic transfusion reaction (DHTR) has been widely recognized as a serious complication of red blood cell transfusion in patients with sickle cell disease (SCD), there is no consensus on its optimal management. Discontinuation of transfusion is recommended, whereas corticosteroids and immunoglobulins are considered to be beneficial. We report 2 children with sickle cell anemia who were diagnosed with DHTR and experienced a subsequent neurologic event in the course of treatment with corticosteroids. The role of corticosteroids as possible precipitating factors of neurologic complications is discussed. Pending a better understanding of the chain of events of DHTR, SCD children with DHTR should receive steroids with great caution.
- Subjects :
- Adolescent
Anemia, Hemolytic drug therapy
Anemia, Sickle Cell blood
Brain Diseases diagnosis
Child
Female
Hemoglobinuria etiology
Hemolysis
Humans
Immunoglobulins analysis
Magnetic Resonance Imaging
Anemia, Hemolytic etiology
Anemia, Sickle Cell therapy
Brain Diseases chemically induced
Erythrocyte Transfusion adverse effects
Glucocorticoids adverse effects
Prednisolone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 30
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19131783
- Full Text :
- https://doi.org/10.1097/MPH.0b013e31818c9172