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Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter.
- Source :
-
Journal of geriatric psychiatry and neurology [J Geriatr Psychiatry Neurol] 2009 Mar; Vol. 22 (1), pp. 35-45. Date of Electronic Publication: 2009 Jan 15. - Publication Year :
- 2009
-
Abstract
- Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74+6 years) and 12 NC (75+4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer's disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers.
- Subjects :
- Aged
Aging
Brain Mapping methods
Female
Humans
Imaging, Three-Dimensional methods
Male
Memory, Short-Term
Mental Recall
Neuropsychological Tests statistics & numerical data
Organ Size
Severity of Illness Index
Task Performance and Analysis
Tomography, Emission-Computed, Single-Photon methods
Alzheimer Disease pathology
Cerebral Cortex pathology
Cerebrovascular Circulation
Cognition Disorders pathology
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 0891-9887
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of geriatric psychiatry and neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19150973
- Full Text :
- https://doi.org/10.1177/0891988708328212