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[Clinical features of paclitaxel-induced peripheral neuropathy and role of Gosya-jinki-gan].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2009 Jan; Vol. 36 (1), pp. 89-92. - Publication Year :
- 2009
-
Abstract
- Paclitaxel (PTX) is frequently used for a chemotherapy of breast cancer and gynecologic cancer. Besides a bone-marrow depression and hypersensitive reaction, the peripheral neuropathy is one of the serious adverse events of PTX. The mechanism of peripheral neuropathy has not been clarified, and few agents have been reported to be effective for the treatment and the prevention of that. Recently, it has been reported that Gosya-jinki-gan is useful for the PTX induced peripheral neuropathy, so we carried a retrospective study(n=82)to evaluate the effectiveness of Gosya-jinkigan with the medical records. It is suggested that peripheral neuropathy developed more rapidly in sequential administration of PTX every week than in administration in 4 weeks cycles consisting of 3 weeks on and 1 week off(5.4w vs. 9.4w). We have also found that Gosya-jinki-gan was possibly effective for the treatment and the prevention of peripheral neuropathy. Additionally Gosya-jinki-gan might be more effective for peripheral neuropathy when it is administered from the beginning of chemotherapy including PTX.
- Subjects :
- Breast Neoplasms drug therapy
Drug Therapy, Combination
Drugs, Chinese Herbal
Female
Genital Neoplasms, Female drug therapy
Humans
Paclitaxel therapeutic use
Surveys and Questionnaires
Vitamins therapeutic use
Paclitaxel adverse effects
Peripheral Nervous System Diseases chemically induced
Peripheral Nervous System Diseases drug therapy
Plant Extracts therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 19151569