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[A case of type B chronic hepatitis showing rapid progression to liver cirrhosis with prolonged positive IgM anti-HBc].
- Source :
-
[Hokkaido igaku zasshi] The Hokkaido journal of medical science [Hokkaido Igaku Zasshi] 1991 Jul; Vol. 66 (4), pp. 575-81. - Publication Year :
- 1991
-
Abstract
- We reported a case of type B chronic hepatitis with high titer of IgM anti-HBc continuously, which progressed to liver cirrhosis rapidly. The patient was a 37-years-old man, and was diagnosed as chronic type B hepatitis with severe activity by laparoscopy and liver biopsy. The titer of IgM anti-HBc persisted high level for more than 2 years. Then the second liver biopsy showed the progression to liver cirrhosis within only about 2 years. It is a very rare case to prolong positive IgM anti-HBc for such a long time. Anti-HBc production of PBMC was enhanced remarkably in this case. We considered that HBc antigens released into serum from hepatocytes with severe exacerbations had enhanced the anti-HBc producing activity of B lymphocytes. And the rapid progression in this case would be due to the episodes of severe exacerbations.
Details
- Language :
- Japanese
- ISSN :
- 0367-6102
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- [Hokkaido igaku zasshi] The Hokkaido journal of medical science
- Publication Type :
- Academic Journal
- Accession number :
- 1916632