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In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth.
- Source :
-
Journal of virology [J Virol] 2009 Apr; Vol. 83 (8), pp. 3617-25. Date of Electronic Publication: 2009 Feb 04. - Publication Year :
- 2009
-
Abstract
- The broadly neutralizing human monoclonal antibodies (MAbs) 2F5 and 4E10, both targeting the highly conserved human immunodeficiency virus type 1 (HIV-1) envelope membrane proximal external region (MPER), are among the MAbs with the broadest heterologous neutralizing activity and are of considerable interest for HIV-1 vaccine development. We have identified serum antibodies from an HIV-infected subject that both were broadly neutralizing and specifically targeted MPER epitopes that overlap the 2F5 epitope. These MPER-specific antibodies were made 15 to 20 months following transmission and concomitantly with the development of autoantibodies. Our findings suggest that multiple events (i.e., genetic predisposition and HIV-1 immune dysregulation) may be required for induction of broadly reactive gp41 MPER antibodies in natural infection.
- Subjects :
- Amino Acid Sequence
Antibodies, Monoclonal immunology
Female
HIV Infections virology
Humans
Molecular Sequence Data
Neutralization Tests
Time Factors
Epitopes immunology
HIV Antibodies blood
HIV Antibodies immunology
HIV Envelope Protein gp41 immunology
HIV Infections immunology
HIV-1 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 83
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 19193787
- Full Text :
- https://doi.org/10.1128/JVI.02631-08