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FR290581, a novel sordarin derivative: synthesis and antifungal activity.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Mar 01; Vol. 19 (5), pp. 1465-8. Date of Electronic Publication: 2009 Jan 22. - Publication Year :
- 2009
-
Abstract
- Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19196509
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.01.051