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Apoptotic-related protein changes induced by hexavalent chromium in mice liver.

Authors :
Wang XF
Lou XM
Shen Y
Xing ML
Xu LH
Source :
Environmental toxicology [Environ Toxicol] 2010 Feb; Vol. 25 (1), pp. 77-82.
Publication Year :
2010

Abstract

Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl-2, Bax, cytochrome c, and caspase-3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase-3 and downregulate the expression of Bcl-2 in mice liver. All these results suggested that p53, Bcl-2, Bax, cytochrome c, and caspase-3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo.

Details

Language :
English
ISSN :
1522-7278
Volume :
25
Issue :
1
Database :
MEDLINE
Journal :
Environmental toxicology
Publication Type :
Academic Journal
Accession number :
19219935
Full Text :
https://doi.org/10.1002/tox.20478