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Apoptotic-related protein changes induced by hexavalent chromium in mice liver.
- Source :
-
Environmental toxicology [Environ Toxicol] 2010 Feb; Vol. 25 (1), pp. 77-82. - Publication Year :
- 2010
-
Abstract
- Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl-2, Bax, cytochrome c, and caspase-3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase-3 and downregulate the expression of Bcl-2 in mice liver. All these results suggested that p53, Bcl-2, Bax, cytochrome c, and caspase-3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo.
- Subjects :
- Animals
Apoptosis Regulatory Proteins genetics
DNA Damage
Gene Expression Profiling
Gene Expression Regulation drug effects
Lethal Dose 50
Male
Mice
Apoptosis drug effects
Apoptosis physiology
Apoptosis Regulatory Proteins metabolism
Liver drug effects
Liver metabolism
Potassium Dichromate toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1522-7278
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Environmental toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 19219935
- Full Text :
- https://doi.org/10.1002/tox.20478