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Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats.
- Source :
-
World journal of urology [World J Urol] 2009 Aug; Vol. 27 (4), pp. 547-55. Date of Electronic Publication: 2009 Feb 17. - Publication Year :
- 2009
-
Abstract
- Introduction: Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options.<br />Materials and Methods: In this study, the changes in bone structure under standardized testosterone- (T), raloxifene- (R) and estrogen (E)-supplemented diets were analyzed in osteoporotic castrated male rats.<br />Results: Unexpected biomechanical results could be only explained by the histomorphometry, but not by BMD measurements obtained from the qCT. All tested substances showed a significant improvement in the trabecular network (trabecular bone area for C: 2.55 mm(2), T: 4.25 mm(2), R: 4.22 mm(2) and E: 4.28 mm(2)), and suggests that the bone structure was preserved. For the metaphyseal cortical bone, a significant loss was detected in T (CBP: 18.7%) compared to R (CBP: 30.0%), E (CBP: 26.8%) and even to the osteoporotic control (CBP: 28.6%). This explains the observed early mechanical final failure after T supplementation. However, due to the preserved trabecular bone in T, the occurrence of the first microfractures (yL: 49 +/- 21.4 N) was significantly later than in the osteoporotic control (yL: 39.5 +/- 15.5 N). Raloxifene performed well in hindering the bone loss associated with osteoporosis. However, its effect (yL: 83.3 +/- 16.5 N) did not approach the protective effect of E (yL: 99.2 +/- 21.1 N).<br />Conclusion: Testosterone only preserved the deterioration of the trabecular bone but not of the cortical bone. Raloxifene prevented the bone loss associated with osteoporosis at all bony structures. This effect did not approach the protective effect of estrogen on trabecular bone, but it is more suitable for male individuals because it has no feminizing effects on the subject.
- Subjects :
- Administration, Oral
Animals
Biomechanical Phenomena
Bone Density drug effects
Bone Density physiology
Bone Resorption drug therapy
Bone Resorption physiopathology
Bone and Bones drug effects
Bone and Bones pathology
Disease Models, Animal
Estrogens administration & dosage
Estrogens pharmacology
Male
Osteoporosis etiology
Osteoporosis physiopathology
Raloxifene Hydrochloride administration & dosage
Raloxifene Hydrochloride pharmacology
Rats
Rats, Sprague-Dawley
Testosterone administration & dosage
Testosterone pharmacology
Bone and Bones physiopathology
Estrogens therapeutic use
Hormone Replacement Therapy
Orchiectomy adverse effects
Osteoporosis drug therapy
Raloxifene Hydrochloride therapeutic use
Testosterone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1433-8726
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- World journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 19221760
- Full Text :
- https://doi.org/10.1007/s00345-009-0373-5