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Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2009 May; Vol. 94 (5), pp. 1732-9. Date of Electronic Publication: 2009 Feb 17. - Publication Year :
- 2009
-
Abstract
- Background: Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study.<br />Methods: From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles.<br />Results: Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)].<br />Conclusions: The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.
- Subjects :
- Adult
Aged
Cardiovascular Diseases genetics
Cardiovascular Diseases mortality
Female
Follow-Up Studies
Humans
Insulin-Like Growth Factor Binding Protein 3 blood
Insulin-Like Growth Factor I metabolism
Male
Middle Aged
Neoplasms genetics
Neoplasms mortality
Proportional Hazards Models
Socioeconomic Factors
Young Adult
Insulin-Like Growth Factor Binding Protein 3 genetics
Insulin-Like Growth Factor I genetics
Mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 94
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19223521
- Full Text :
- https://doi.org/10.1210/jc.2008-2138