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Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2009 May; Vol. 53 (5), pp. 2153-5. Date of Electronic Publication: 2009 Feb 17. - Publication Year :
- 2009
-
Abstract
- We have evaluated the efficacies of micafungin, amphotericin B, and voriconazole, alone and in double and triple combinations, in a murine model of systemic infection by Scedosporium prolificans. Micafungin combined with voriconazole or amphotericin B was the most effective, these being the only treatments able to prolong survival and to reduce the fungal load in the kidneys and brain. Triple combinations of these drugs did not improve the results obtained with double combinations.
- Subjects :
- Animals
Brain microbiology
Disease Models, Animal
Drug Resistance, Fungal
Drug Therapy, Combination
Humans
Kidney microbiology
Male
Micafungin
Mice
Microbial Sensitivity Tests
Mycetoma microbiology
Mycetoma mortality
Scedosporium classification
Scedosporium isolation & purification
Treatment Outcome
Voriconazole
Amphotericin B administration & dosage
Amphotericin B therapeutic use
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Echinocandins administration & dosage
Echinocandins therapeutic use
Lipopeptides administration & dosage
Lipopeptides therapeutic use
Mycetoma drug therapy
Pyrimidines administration & dosage
Pyrimidines therapeutic use
Scedosporium drug effects
Triazoles administration & dosage
Triazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 53
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 19223617
- Full Text :
- https://doi.org/10.1128/AAC.01477-08