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Endothelin system polymorphisms in tilt test-induced vasovagal syncope.
- Source :
-
Clinical autonomic research : official journal of the Clinical Autonomic Research Society [Clin Auton Res] 2009 Apr; Vol. 19 (2), pp. 123-9. Date of Electronic Publication: 2009 Feb 19. - Publication Year :
- 2009
-
Abstract
- Objectives: As the endothelin system participates in the regulation of cardiovascular homeostasis, the aim of this study was to analyse the role of endothelin system polymorphisms in influencing tilt-induced vasovagal syncope.<br />Methods: We evaluated 107 otherwise healthy subjects with recurrent unexplained syncope who underwent a head-up tilt test. All subjects were genotyped for the 3A/4A polymorphism of the EDN1 gene and the H323H T/C polymorphism of the EDNRA gene.<br />Results: Fifty-eight patients (54%) fainted. In terms of the EDNRA polymorphism, eight subjects (8%) had the T/T genotype, 41 were heterozygous (38%) and 58 homozygous (54%) for the C allele. Sixty subjects (56%) carried homozygosis for the 3A allele of the EDN1 polymorphism and 47 were heterozygous (44%). The 4A allele was significantly more frequent in the patients who responded positively to the tilt test than in those who did not: the relative odds ratios and confidence intervals at univariate and multivariate analyses were respectively 2.37 (1.07-5.26) and 2.41 (1.05-5.49). Comparisons with a control group further supported these data. Among the tilt-positive patients, the carriers of the 4A allele were more likely to have a vasodepressive pattern than those who were homozygous for the 3A variant.<br />Interpretation: The 3A/4A polymorphism of the EDN1 gene affects susceptibility to syncope, and the 4A variant associated with increased endothelin-1 expression may promote vasodepressive hemodynamic responses during tilt testing.
Details
- Language :
- English
- ISSN :
- 1619-1560
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical autonomic research : official journal of the Clinical Autonomic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 19225824
- Full Text :
- https://doi.org/10.1007/s10286-009-0519-y