Synthesis of spiroheterocycles by palladium-catalyzed domino cycloisomerization/cross-coupling of alpha-allenols and Baylis-Hillman acetates.

First insights into the reaction between a Baylis-Hillman adduct and an allene moiety have been obtained from the novel domino heterocyclization/cross-coupling reaction of alpha-allenols and Baylis-Hillman acetates, which furnishes [(2,5-dihydrofuran-3-yl)methyl]acrylate derivatives in moderate to good yields.