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Characteristics of Alzheimer's disease patients with a rapid weight loss during a six-year follow-up.
- Source :
-
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2009 Apr; Vol. 28 (2), pp. 141-6. Date of Electronic Publication: 2009 Feb 20. - Publication Year :
- 2009
-
Abstract
- Background & Aims: Weight loss in Alzheimer's disease (AD) may be either progressive or rapid, with different consequences. The aim of this study was to characterize massive weight loss (>or= 5 kg over 6 months) during a 6.5-year follow-up.<br />Methods: 395 patients with AD (mean age 75.4 years) were included in a prospective single-centre cohort study (mean follow-up 2.5 years). A standardized gerontologic assessment was performed every six months, including nutritional, neuropsychological, functional, and caregiver burden evaluations, along with recording all intercurrent events before weight loss.<br />Results: Among the 127 cases of weight loss (in 110 subjects, 27.8% of the population), we identified 60 cases of intercurrent illnesses and 88 cases of behavioral and psychological symptoms of dementia (BPSD) during the six months before weight loss. Three factors were independently associated with rapid weight loss: higher initial weight (HR=1.06, 95% CI [1.02, 1.08]), higher Prognosis Inflammatory and Nutritional Index (HR=2.16, 95% CI [1.26, 3.72]) and a higher Cohen-Mansfield agitation inventory score, reflecting BPSD (HR=1.05, 95% CI [1.01, 1.10]). Cholinesterase inhibitors appeared as protective (HR=0.33, 95% CI [0.15, 0.73]). Rapid weight loss was predictive of death at 6 months (HR=3.01, 95% CI [1.73, 5.22]).<br />Conclusion: BPSD play an important role in rapid weight loss and should be managed effectively. Biological assessment of malnutrition may be warranted.
- Subjects :
- Aged
Cohort Studies
Comorbidity
Female
Follow-Up Studies
France epidemiology
Geriatric Assessment methods
Geriatric Assessment statistics & numerical data
Humans
Longitudinal Studies
Male
Nutrition Assessment
Nutritional Status
Prospective Studies
Time
Alzheimer Disease epidemiology
Malnutrition epidemiology
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 19232792
- Full Text :
- https://doi.org/10.1016/j.clnu.2009.01.014