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Management of a pregnancy complicated by yolk sac tumor.

Authors :
Pafilis I
Haidopoulos D
Rodolakis A
Vlachos G
Voulgaris Z
Sotiropoulou M
Antsaklis A
Source :
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2009 Nov; Vol. 280 (5), pp. 803-6. Date of Electronic Publication: 2009 Feb 21.
Publication Year :
2009

Abstract

Background: The management of ovarian cancer during pregnancy represents a major challenge and requires close multidisciplinary team approach.<br />Case: A 35-year-old pregnant woman with a yolk sac tumor underwent left salpingo-oophorectomy at 25 weeks of gestation. Chemotherapy was deferred to the end of the pregnancy owing to concerns for potential fetal risks. Alpha-feto protein level was used to monitor the underlying disease activity. The patient underwent exploratory laparotomy with cesarean section followed by total hysterectomy, omentectomy, right salpingooophorectomy, pelvic, and para-aortic lymphadenectomies at 32 weeks of gestation. She received four postoperative courses of chemotherapy (cisplatin, etoposide, and peplomycin). Currently, mother and child are doing well 6 months after the last chemotherapy cycle.<br />Conclusion: In a case of yolk sac tumor in the second trimester of pregnancy, radical surgery combined with elective caesarian section followed by chemotherapy could achieve remission and rescue of fetus. However, the treatment needs to be individualized as there is lack of evidence.

Details

Language :
English
ISSN :
1432-0711
Volume :
280
Issue :
5
Database :
MEDLINE
Journal :
Archives of gynecology and obstetrics
Publication Type :
Academic Journal
Accession number :
19234710
Full Text :
https://doi.org/10.1007/s00404-009-0977-4