Back to Search
Start Over
Squamous cell carcinoma associated with intralesional injection of cidofovir for recurrent respiratory papillomatosis.
- Source :
-
The Laryngoscope [Laryngoscope] 2009 Mar; Vol. 119 (3), pp. 567-70. - Publication Year :
- 2009
-
Abstract
- Recurrent respiratory papillomatosis is a common neoplasm of the larynx that may lead to severe, recurrent lesions. Intralesional injection of cidofovir has shown promise as an adjuvant therapy. There is concern for possible malignant transformation with its use but, to our knowledge, this has not been documented in the literature. We report a case of invasive squamous cell cancer arising from squamous papilloma in a patient treated with multiple injections of cidofovir. Although causation is not shown, we believe the association presented is a valuable addition to the literature and an important consideration in the use of cidofovir.
- Subjects :
- Antineoplastic Agents administration & dosage
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell surgery
Child
Cidofovir
Cytosine administration & dosage
Cytosine adverse effects
Female
Follow-Up Studies
Humans
Injections, Intralesional adverse effects
Neoplasms, Second Primary diagnosis
Neoplasms, Second Primary surgery
Organophosphonates administration & dosage
Otorhinolaryngologic Surgical Procedures methods
Papilloma diagnostic imaging
Papilloma pathology
Tomography, X-Ray Computed
Trachea surgery
Tracheal Neoplasms diagnosis
Tracheal Neoplasms surgery
Antineoplastic Agents adverse effects
Carcinoma, Squamous Cell chemically induced
Cytosine analogs & derivatives
Neoplasms, Second Primary chemically induced
Organophosphonates adverse effects
Papilloma drug therapy
Tracheal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 119
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 19235765
- Full Text :
- https://doi.org/10.1002/lary.20082