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Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2008 Oct-Dec; Vol. 9 (4), pp. 781-4. - Publication Year :
- 2008
-
Abstract
- The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this study was to determine whether the use of Ki-67 and p53 could help in solving the above dilemma. This was a retrospective study on 61 cases of cervical neoplasms comprising of 25 cases of CIN 3 and 36 SCC. All cases were evaluated by immunohistochemistry using Ki-67 and p53 monoclonal antibodies. Results showed that the differences of Ki-67 and p53 expression between CIN 3 and SCC were statistically significant. In conclusion, Ki-67 and p53 may serve as helpful adjuncts to routinely-stained histological sections in differentiating between CIN 3 and SCC.
- Subjects :
- Adult
Aged
Biopsy, Needle
Carcinoma, Squamous Cell pathology
Cohort Studies
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Malaysia
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Uterine Cervical Neoplasms pathology
Uterine Cervical Dysplasia pathology
Biomarkers, Tumor analysis
Carcinoma, Squamous Cell chemistry
Ki-67 Antigen analysis
Tumor Suppressor Protein p53 analysis
Uterine Cervical Neoplasms chemistry
Uterine Cervical Dysplasia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 19256776