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CD98hc facilitates B cell proliferation and adaptive humoral immunity.
- Source :
-
Nature immunology [Nat Immunol] 2009 Apr; Vol. 10 (4), pp. 412-9. Date of Electronic Publication: 2009 Mar 08. - Publication Year :
- 2009
-
Abstract
- The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total suppression of B cell proliferation and subsequent plasma cell formation. Deletion of CD98hc did not impair early B cell activation but did inhibit later activation of the mitogen-activated protein kinase Erk1/2 and downregulation of the cell cycle inhibitor p27. Reconstitution of CD98hc-deficient B cells with CD98hc mutants showed that the integrin-binding domain of CD98hc was required for B cell proliferation but that the amino acid-transport function of CD98hc was dispensable for this. Thus, CD98hc supports integrin-dependent rapid proliferation of B cells. We propose that the advantage of adaptive immunity favored the appearance of CD98hc in vertebrates.
- Subjects :
- Animals
B-Lymphocytes cytology
Biological Transport, Active
Cell Differentiation physiology
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p27 metabolism
Integrins metabolism
Lymphocyte Activation
Mice
Mice, Transgenic
Mitogen-Activated Protein Kinase 3 metabolism
Plasma Cells cytology
Plasma Cells immunology
Protein Binding
Antibody Formation
B-Lymphocytes immunology
Cell Proliferation
Fusion Regulatory Protein 1, Heavy Chain immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 19270713
- Full Text :
- https://doi.org/10.1038/ni.1712