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Intravenous administration of nicorandil immediately before percutaneous coronary intervention can prevent slow coronary flow phenomenon.
- Source :
-
European heart journal [Eur Heart J] 2009 Apr; Vol. 30 (7), pp. 765-72. Date of Electronic Publication: 2009 Mar 10. - Publication Year :
- 2009
-
Abstract
- Aims: To determine the effect of intravenous administration of nicorandil on slow coronary flow (SCF) phenomenon in patients undergoing percutaneous coronary intervention (PCI).<br />Methods and Results: In a preliminary study, 6 mg of nicorandil showed optimal efficacy for vasodilatation without causing significant haemodynamic instability. In the main study, a total of 408 patients were randomly assigned to receive intravenous administration of 6 mg of nicorandil immediately before PCI. The number of patients in the nicorandil group was 206 [acute coronary syndrome (ACS): 47, non-ACS: 159] and that in the control group was 202 (ACS: 61, non-ACS: 141). Nicorandil significantly decreased the incidence of post-procedural SCF phenomenon in both the ACS and non-ACS groups. The rate of target vessel revascularization (TVR) was significantly lower in the nicorandil group than in the control group in ACS patients.<br />Conclusion: Our simple procedure prevented SCF phenomenon not only in patients with ACS but also in patients with non-ACS without any adverse effect. Additionally our procedure reduced the rate of TVR in patients with ACS.
- Subjects :
- Acute Coronary Syndrome physiopathology
Aged
Angina Pectoris physiopathology
Coronary Angiography
Coronary Circulation physiology
Double-Blind Method
Female
Humans
Injections, Intravenous
Male
Prospective Studies
Treatment Outcome
Acute Coronary Syndrome therapy
Angina Pectoris drug therapy
Angioplasty, Balloon, Coronary adverse effects
Anti-Arrhythmia Agents administration & dosage
Coronary Circulation drug effects
Nicorandil administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1522-9645
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 19276198
- Full Text :
- https://doi.org/10.1093/eurheartj/ehp077