Back to Search
Start Over
Polyfunctional CD4+ T-cell induction in neutralizing antibody-triggered control of simian immunodeficiency virus infection.
- Source :
-
Journal of virology [J Virol] 2009 Jun; Vol. 83 (11), pp. 5514-24. Date of Electronic Publication: 2009 Mar 18. - Publication Year :
- 2009
-
Abstract
- Rapid depletion of memory CD4(+) T cells and delayed induction of neutralizing antibody (NAb) responses are characteristics of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections. Although it was speculated that postinfection NAb induction could have only a limited suppressive effect on primary HIV replication, a recent study has shown that a single passive NAb immunization of rhesus macaques 1 week after SIV challenge can result in reduction of viral loads at the set point, indicating a possible contribution of postinfection NAb responses to virus control. However, the mechanism accounting for this NAb-triggered SIV control has remained unclear. Here, we report rapid induction of virus-specific polyfunctional T-cell responses after the passive NAb immunization postinfection. Analysis of SIV Gag-specific responses of gamma interferon, tumor necrosis factor alpha, interleukin-2, macrophage inflammatory protein 1beta, and CD107a revealed that the polyfunctionality of Gag-specific CD4(+) T cells, as defined by the multiplicity of these responses, was markedly elevated in the acute phase in NAb-immunized animals. In the chronic phase, despite the absence of detectable NAbs, virus control was maintained, accompanied by polyfunctional Gag-specific T-cell responses. These results implicate virus-specific polyfunctional CD4(+) T-cell responses in this NAb-triggered virus control, suggesting possible synergism between NAbs and T cells for control of HIV/SIV replication.
- Subjects :
- Acute-Phase Reaction immunology
Animals
Antibodies, Viral pharmacology
CD4-Positive T-Lymphocytes drug effects
CD8-Positive T-Lymphocytes immunology
Gene Products, gag immunology
Immunization
Macaca mulatta
Antibodies, Viral immunology
CD4-Positive T-Lymphocytes immunology
Simian Acquired Immunodeficiency Syndrome immunology
Simian Immunodeficiency Virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 83
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 19297503
- Full Text :
- https://doi.org/10.1128/JVI.00145-09