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Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.

Authors :
Yosifova A
Mushiroda T
Stoianov D
Vazharova R
Dimova I
Karachanak S
Zaharieva I
Milanova V
Madjirova N
Gerdjikov I
Tolev T
Velkova S
Kirov G
Owen MJ
O'Donovan MC
Toncheva D
Nakamura Y
Source :
Journal of affective disorders [J Affect Disord] 2009 Sep; Vol. 117 (1-2), pp. 87-97. Date of Electronic Publication: 2009 Mar 28.
Publication Year :
2009

Abstract

Background: Bipolar affective disorder (BAD) is a psychiatric illness characterized by episodes of mania and depression. Although the etiology is not clear, epidemiological studies suggest it is a result of an interaction of genetic and environmental factors. Despite of enormous efforts and abundant studies conducted, none has yet been identified definitively a gene susceptible to bipolar disorder.<br />Methods: Ninety-four Bulgarian patients diagnosed with bipolar disorder and 184 Bulgarian healthy individuals, were used for genotyping of 191 single nucleotide polymorphisms (SNPs) by TaqMan and/or Invader assays. Seventeen SNPs that revealed P value less than 0.05 in the first screening were genotyped using an additional independent set of samples, consisting of 78 BAD cases and 372 controls.<br />Results: After applying the Bonferonni correction on genotyping results of 172 cases and 556 controls, only one SNP, rs1800883, in the HTR5A gene revealed a significant level of P value (P=0.000097; odds ratio=1.80 (95%CI, 1.27-2.54); corrected P=0.017).<br />Conclusions: Our findings suggest that HTR5A gene could play an important role in the pathogenesis of bipolar disorder in our population. However these findings should be viewed with caution and replication studies in other populations are necessary in support of these findings.

Details

Language :
English
ISSN :
1573-2517
Volume :
117
Issue :
1-2
Database :
MEDLINE
Journal :
Journal of affective disorders
Publication Type :
Academic Journal
Accession number :
19328558
Full Text :
https://doi.org/10.1016/j.jad.2008.12.021