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Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2009 Apr; Vol. 80 (4), pp. 541-6. - Publication Year :
- 2009
-
Abstract
- Damage to the cerebral microvasculature is a feature of cerebral malaria. Circulating endothelial progenitor cells are needed for microvascular repair. Based on this knowledge, we hypothesized that the failure to mobilize sufficient circulating endothelial progenitor cells to the cerebral microvasculature is a pathophysiologic feature of cerebral malaria. To test this hypothesis, we compared peripheral blood levels of CD34 (+)/VEGFR2(+) and CD34 (+)/CD133(+) cells and plasma levels of the chemokine stromal cell-derived growth factor 1 (SDF-1) in 214 children in Accra, Ghana. Children with cerebral malaria had lower levels of CD34 (+)/VEGFR2(+) and CD34 (+)/CD133(+) cells compared with those with uncomplicated malaria, asymptomatic parasitemia, or healthy controls. SDF-1 levels were higher in children with acute malaria compared with healthy controls. Together, these results uncover a potentially novel role for endothelial progenitor cell mobilization in the pathophysiology of cerebral malaria.
- Subjects :
- AC133 Antigen
Antigens, CD analysis
Antigens, CD34 analysis
Chemokines genetics
Chemokines metabolism
Child
Child, Preschool
Endothelial Cells chemistry
Female
Flow Cytometry
Gene Expression Regulation
Ghana epidemiology
Glycoproteins analysis
Humans
Infant
Malaria, Cerebral epidemiology
Male
Peptides analysis
Stem Cells chemistry
Vascular Endothelial Growth Factor Receptor-2 analysis
Endothelial Cells cytology
Malaria, Cerebral pathology
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 80
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 19346372