Back to Search
Start Over
Spontaneous urinary calcium oxalate crystallization in hypercalciuric children.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2009 Sep; Vol. 24 (9), pp. 1705-10. Date of Electronic Publication: 2009 Apr 07. - Publication Year :
- 2009
-
Abstract
- Idiopathic hypercalciuria is the most important predisposing risk factor for calcium oxalate (CaOx) renal stone formation. We assessed the associations between spontaneous CaOx crystallization based on the Bonn Risk Index (BRI), urinary pH, calciuria, oxaluria, and citraturia in 140 Caucasian patients with hypercalciuria, aged 4-17 years, and compared the findings with those in 210 normocalciuric controls. Of the 140 hypercalciuric patients, 58 had renal stones, and 82 had recurrent erythrocyturia, renal colic, or urinary obstructive symptoms-but without stones. Urinary ionized calcium ([Ca(2+)]) levels were measured using a selective electrode, while the onset of crystallization was determined using a photometer and titration with 40 mmol/L ammonium oxalate (Ox(2-)). The calculation of the BRI was based on the [Ca(2+)]:Ox(2-) ratio. The BRI values were 12-fold higher in hypercalciuric children than in healthy controls, but no differences were found in the BRI between subjects with urinary stones and those with urolithiasis-like symptoms. An increased BRI suggested an association with hypercalciuria, lower urinary pH, hypocitraturia, and hypooxaluria. These data indicate that hypercalciuria is an important factor associated with increased urinary CaOx crystallization, although the causal pathways need further investigation. Determination of the BRI in children with hypercalciuria may improve the risk assessment of kidney stones.
- Subjects :
- Adolescent
Child
Child, Preschool
Comorbidity
Crystallization
Female
Humans
Hydrogen-Ion Concentration
Hypercalciuria diagnosis
Hypercalciuria epidemiology
Kidney Calculi diagnosis
Kidney Calculi epidemiology
Male
Poland epidemiology
Risk Factors
Urinalysis
Calcium Oxalate urine
Hypercalciuria urine
Kidney Calculi urine
Subjects
Details
- Language :
- English
- ISSN :
- 1432-198X
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 19350280
- Full Text :
- https://doi.org/10.1007/s00467-009-1171-4