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Clinical experience with the combined use of lopinavir/ritonavir and rifampicin.
- Source :
-
AIDS (London, England) [AIDS] 2009 Apr 27; Vol. 23 (7), pp. 863-5. - Publication Year :
- 2009
-
Abstract
- Thirty-four patients treated concomitantly with lopinavir/ritonavir and rifampicin were evaluated. Overall, only 15% used the recommended increased dose of lopinavir/ritonavir. Of patients on a nonadjusted dose of lopinavir/ritonavir, 67% had a subtherapeutic lopinavir plasma concentration and 38% had a detectable viral load. Forty percent of patients on an increased dose of lopinavir/ritonavir prematurely stopped the drug combination because of adverse events. Combined use of lopinavir/ritonavir and rifampicin is challenging as it implies balancing between suboptimal efficacy and toxicity.
- Subjects :
- Adult
Drug Administration Schedule
Drug Therapy, Combination
Female
HIV Infections virology
Humans
Lopinavir
Male
Viral Load
HIV Infections drug therapy
HIV Protease Inhibitors administration & dosage
HIV-1
Pyrimidinones administration & dosage
Rifampin administration & dosage
Ritonavir administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 19352137
- Full Text :
- https://doi.org/10.1097/QAD.0b013e328329148e