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Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2009 May; Vol. 30 (5), pp. 260-7. Date of Electronic Publication: 2009 Apr 09. - Publication Year :
- 2009
-
Abstract
- In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for transplantation. Recent studies demonstrate that cells with properties of mesencephalic DA neurons can be produced from stem cells of different sources including reprogrammed somatic cells. However, as we discuss here, it remains to be shown that these cells can provide efficient functional reinnervation and behavioral recovery in animal PD models. Moreover, a clinically competitive cell therapy for PD will require better criteria for patient selection, improved functional efficacy of grafts by a tailor-made transplantation procedure providing optimum repair of the patient's DA system and strategies to prevent dyskinesias and tumor formation.
- Subjects :
- Animals
Clinical Protocols
Clinical Trials as Topic
Dopamine deficiency
Dopamine physiology
Humans
Mesenchymal Stem Cell Transplantation adverse effects
Neurons pathology
Parkinson Disease pathology
Patient Selection
Mesenchymal Stem Cell Transplantation methods
Neurons transplantation
Parkinson Disease therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0165-6147
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 19362379
- Full Text :
- https://doi.org/10.1016/j.tips.2009.03.001