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Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia.

Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia.

Authors :
Kristinsson SY
Koshiol J
Goldin LR
Björkholm M
Turesson I
Gridley G
McMaster ML
Landgren O
Source :
Clinical lymphoma & myeloma [Clin Lymphoma Myeloma] 2009 Mar; Vol. 9 (1), pp. 23-6.
Publication Year :
2009

Abstract

There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

Details

Language :
English
ISSN :
1557-9190
Volume :
9
Issue :
1
Database :
MEDLINE
Journal :
Clinical lymphoma & myeloma
Publication Type :
Academic Journal
Accession number :
19362964
Full Text :
https://doi.org/10.3816/CLM.2009.n.004