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The first recognized epigenetic signal: DNA glucosylation of T-even bacteriopages.
- Source :
-
Epigenetics [Epigenetics] 2009 Apr 01; Vol. 4 (3), pp. 150-1. Date of Electronic Publication: 2009 Apr 14. - Publication Year :
- 2009
-
Abstract
- Host-induced modification of phage T2 to T*2 was discovered in 1952. This phenomenon, a reversible alteration in viral host range resulting from a single growth cycle in certain bacterial hosts, is an 'epigenetic' change. In 1963 the chemical basis for the T* modification was shown to be the loss of DNA glucosylation, which resulted from T-even phage growth in cells lacking the glucosyl donor UDPG. Thus, DNA glucosylation of T-even phages was the first recognized epigenetic signal.
- Subjects :
- Glycosylation
DNA, Viral metabolism
Epigenesis, Genetic
T-Phages genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1559-2308
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- 19372753
- Full Text :
- https://doi.org/10.4161/epi.4.3.8444