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Long-term survival after surgery for primary hepatic sarcoma in adults.
- Source :
-
Archives of surgery (Chicago, Ill. : 1960) [Arch Surg] 2009 Apr; Vol. 144 (4), pp. 339-44; discussion 344. - Publication Year :
- 2009
-
Abstract
- Hypothesis: Patients with primary hepatic sarcomas benefit from resection, with possible long-term cure.<br />Design: Retrospective and prospective cohort study.<br />Setting: University hospitals of Hamburg-Eppendorf and Düsseldorf, Germany.<br />Patients: Between 1985 and 2006, 22 patients (8 men and 14 women; median age at initial diagnosis, 54 years [range, 19-80 years]) were surgically treated for primary hepatic sarcomas.<br />Intervention: Tumor resection with curative intent ranging from nonanatomical resection to liver transplant.<br />Main Outcome Measures: Effects on overall survival were analyzed using the log-rank test.<br />Results: The majority of tumors were more than 5 cm (n = 19), with a median tumor size of 7 cm (range, 4-14 cm); of intermediate differentiation (G2; n = 15); and classified as leiomyosarcoma (n = 7). Ten patients received a hemihepatectomy. In 4 patients, a bisegmentectomy was performed and in 2 patients, a segmentectomy, while 4 patients received a nonanatomical resection. Liver transplant was performed in 2 patients. In 18 patients, complete tumor resection (R0) was achieved. Perioperative mortality was 0%. Median follow-up was 88 months (range, 6-246 months). Local recurrence occurred in 6 patients. Distant metastases were diagnosed in 10 patients, predominantly in the lung (n = 6). The 5-year survival after surgery was 65%, with 41% of the patients living more than 10 years without disease. Patients with angiosarcoma had a poor prognosis (P = .03).<br />Conclusions: Although primary hepatic sarcoma is a rare malignant tumor, no standard treatment is established. A long-term survival is possible after complete tumor resection in a preselected population with early-stage disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Hemangiosarcoma mortality
Hemangiosarcoma surgery
Humans
Liver Neoplasms diagnosis
Liver Neoplasms mortality
Male
Middle Aged
Neoplasm Recurrence, Local
Sarcoma diagnosis
Sarcoma mortality
Sarcoma secondary
Survival Rate
Young Adult
Liver Neoplasms surgery
Sarcoma surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3644
- Volume :
- 144
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of surgery (Chicago, Ill. : 1960)
- Publication Type :
- Academic Journal
- Accession number :
- 19380647
- Full Text :
- https://doi.org/10.1001/archsurg.2009.30