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Improvement of CXCR3 ligand CXCL11/I-TAC measurement in human plasma and serum.
- Source :
-
The new microbiologica [New Microbiol] 2009 Jan; Vol. 32 (1), pp. 125-8. - Publication Year :
- 2009
-
Abstract
- The chemokine receptor CXCR3 is involved in cell trafficking dysregulation associated with several inflammatory conditions, including autoimmune and viral diseases. Downregulation of CXCR3, through binding with its ligand CXCL11 (I-TAC), represents a key mechanism in lymphocyte recruitment. Determination of circulating I-TAC can provide useful information in the investigation of inflammatory/infectious conditions. The existing commercial kit does not measure CXCL11/I-TAC in complex matrices, such as human plasma and serum, as reliably as in in vitro-generated cell culture supernatants. We here describe means which lead to an improvement of CXCL11/I-TAC measurement in human plasma and serum.
Details
- Language :
- English
- ISSN :
- 1121-7138
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The new microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 19382679