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Higher serum 25-hydroxyvitamin D levels in school-age children are inconsistently associated with increased calcium absorption.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2009 Jul; Vol. 94 (7), pp. 2421-7. Date of Electronic Publication: 2009 Apr 21. - Publication Year :
- 2009
-
Abstract
- Context: Increasing serum 25-hydroxyvitamin D (25-OHD) in adults may enhance calcium absorption (Ca-abs). There are few similar pediatric data leading to uncertainty about the optimal target for 25-OHD to maximize Ca-abs.<br />Objective: Our objective was to evaluate the relationship between 25-OHD and Ca-abs in a large cohort of school-age children and adolescents.<br />Design: We evaluated data from 439 Ca-abs measurements performed using dual-tracer stable isotope techniques conducted at our center over a 15-yr period in 251 healthy children, 4.9-16.7 yr of age.<br />Results: Serum 25-OHD ranged from 28 to 197 nmol/liter (mean 85 +/- 2 nmol/liter) (sem). Total Ca-abs (intake times fractional absorption) were significantly correlated to 25-OHD in the whole population (r = 0.16, P = 0.001). This relationship was closer in the 197 studies in early puberty (Tanner 2 or 3, r = 0.35, P < 0.001) and not significant in pre- or late pubertal subjects. For the whole population, fractional Ca-abs adjusted for calcium intake were slightly but significantly higher at 25-OHD of 28-50 nmol/liter (0.344 +/- 0.019) compared with 25-OHD of 50-80 nmol/liter (0.280 +/- 0.014) or 25-OHD greater than 80 nmol/liter (0.297 +/- 0.015, P < 0.01 for each), suggesting adaptation to moderately low 25-OHD values.<br />Conclusion: There is no consistent pattern of relationship between 25-OHD and either fractional or total calcium absorption in school-age children. However, there appears to be a modest calcium absorptive response to higher 25-OHD during early puberty.
- Subjects :
- Absorption
Adolescent
Calcium metabolism
Calcium, Dietary metabolism
Calcium, Dietary pharmacokinetics
Child
Child, Preschool
Eating physiology
Female
Humans
Intestinal Absorption physiology
Male
Population
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency metabolism
Calcium pharmacokinetics
Vitamin D analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 94
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19383779
- Full Text :
- https://doi.org/10.1210/jc.2008-2587