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Kinetoplastid papain-like cysteine peptidases.
- Source :
-
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2009 Sep; Vol. 167 (1), pp. 12-9. Date of Electronic Publication: 2009 May 03. - Publication Year :
- 2009
-
Abstract
- Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.
- Subjects :
- Animals
Antigens, Protozoan immunology
Cysteine Endopeptidases analysis
Cysteine Endopeptidases classification
Cysteine Endopeptidases genetics
Kinetoplastida chemistry
Kinetoplastida genetics
Protozoan Vaccines immunology
Terminology as Topic
Cysteine Endopeptidases physiology
Kinetoplastida enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9428
- Volume :
- 167
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular and biochemical parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 19409421
- Full Text :
- https://doi.org/10.1016/j.molbiopara.2009.04.009