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MicroRNAs and cancer--new paradigms in molecular oncology.

Authors :
Negrini M
Nicoloso MS
Calin GA
Source :
Current opinion in cell biology [Curr Opin Cell Biol] 2009 Jun; Vol. 21 (3), pp. 470-9. Date of Electronic Publication: 2009 May 04.
Publication Year :
2009

Abstract

The 'classic' view of molecular oncology indicates that cancer is a genetic disease involving tumor suppressor and oncogenic proteins. However, in the recent years, it has been demonstrated that small regulatory non-coding RNAs (ncRNAs) named microRNAs (miRNAs) are involved in human tumorigenesis, thus revealing a new layer in the molecular architecture of human cancer. Gene expression studies revealed that hundreds of miRNAs are deregulated in cancer cells and functional studies clarified that miRNAs are involved in all the molecular and biological processes that drive tumorigenesis. Here, we summarize the recent advances in miRNA involvement in human cancer and illustrate the benefits of using these knowledge for medical practice. New diagnostic classifiers based on miRNAs will soon be available for medical practitioners and, even more importantly, miRNAs may become novel anti-cancer tools.

Details

Language :
English
ISSN :
1879-0410
Volume :
21
Issue :
3
Database :
MEDLINE
Journal :
Current opinion in cell biology
Publication Type :
Academic Journal
Accession number :
19411171
Full Text :
https://doi.org/10.1016/j.ceb.2009.03.002