Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

Authors :: Sekiguchi Y
Nakaniwa T
Kinoshita T
Nakanishi I
Kitaura K
Hirasawa A
Tsujimoto G
Tada T
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Jun 01; Vol. 19 (11), pp. 2920-3. Date of Electronic Publication: 2009 Apr 22.
Publication Year :: 2009
Abstract: We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.

Subjects :: Adenosine Triphosphate chemistry
Binding Sites
Casein Kinase II metabolism
Catalytic Domain
Crystallography, X-Ray
Humans
Protein Structure, Tertiary
Casein Kinase II antagonists & inhibitors
Casein Kinase II chemistry
Ellagic Acid chemistry
Enzyme Inhibitors chemistry

Full Text Access

Tools