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Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2009; Vol. 4, pp. 65-71. Date of Electronic Publication: 2009 Apr 01. - Publication Year :
- 2009
-
Abstract
- Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe(3)O(4) (MNP(Fe(3)O(4))) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe(3)O(4)) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe(3)O(4)) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML.
- Subjects :
- Antibiotics, Antineoplastic administration & dosage
Antibiotics, Antineoplastic chemistry
Benzylisoquinolines radiation effects
Daunorubicin chemistry
Drug Carriers radiation effects
Ferric Compounds radiation effects
Humans
K562 Cells
Nanoparticles administration & dosage
Nanoparticles radiation effects
Apoptosis drug effects
Benzylisoquinolines chemistry
Daunorubicin administration & dosage
Drug Carriers chemistry
Ferric Compounds chemistry
Leukemia physiopathology
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 19421371