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Magnetic resonance imaging protocol optimization for delineation of gross tumor volume in hypopharyngeal and laryngeal tumors.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2009 Jun 01; Vol. 74 (2), pp. 630-6. - Publication Year :
- 2009
-
Abstract
- Purpose: To optimize the use of MRI for delineation of gross tumor volume for radiotherapy treatment planning purposes in hypopharyngeal and laryngeal tumors.<br />Methods and Materials: Magnetic resonance images (T1 weighted and T2 weighted) of a healthy volunteer were acquired using a 1.5 T and 3.0 T MR scanner. Various receiver coils were investigated that were compatible with the immobilization mask needed for reliable coregistration with computed tomography data. For the optimal receiver coil, the influence of resolution, slice thickness, and strength of magnetic field on the signal-to-noise ratio (SNR) was studied. Feasibility of the definitive protocol was tested on patients with hypopharyngeal (n = 19) and laryngeal (n = 42) carcinoma.<br />Results: Large differences in SNR were obtained for the various coils. The SNR values obtained using surface coils that were compatible with the immobilization mask were three times higher than those obtained using a standard head-and-neck coil and five times higher than those obtained using a body coil. High-resolution images (0.4 x 0.4 x 4 mm(3)) showed superior anatomic detail and resulted in a 4-min scan time. Image quality at 3.0 T was not significantly better compared with 1.5 T. In 3 patients the MR study could not be performed; for 5 patients images were severely deteriorated by motion artefacts. High-quality MR images were obtained in 53 patients.<br />Conclusions: High-resolution MR images of the hypopharynx and larynx can be obtained in the majority of patients using surface receiver coils in combination with the radiotherapy mask. These MR images can be successfully used for tumor delineation in radiotherapy.
- Subjects :
- Humans
Hypopharyngeal Neoplasms radiotherapy
Laryngeal Neoplasms radiotherapy
Magnetic Resonance Imaging instrumentation
Radiotherapy Planning, Computer-Assisted methods
Radiotherapy, Computer-Assisted methods
Clinical Protocols
Hypopharyngeal Neoplasms pathology
Laryngeal Neoplasms pathology
Magnetic Resonance Imaging methods
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 19427562
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2009.01.014