Back to Search
Start Over
Oligopeptide-modified silicon nanowire arrays as multichannel metal ion sensors.
- Source :
-
Biosensors & bioelectronics [Biosens Bioelectron] 2009 Jul 15; Vol. 24 (11), pp. 3248-51. Date of Electronic Publication: 2009 Apr 16. - Publication Year :
- 2009
-
Abstract
- Semiconducting nanowires have the potential to function as highly sensitive and selective sensors for label-free detection of biological and chemical species. In this paper, we describe the preparation and applications of oligopeptide-modified single crystal silicon nanowire (SiNW) arrays as multichannel metal ion sensors. Because these SiNW arrays were fabricated by using a "top-down" process, a very high density of individually addressable SiNW (180 SiNWs grouped into 36 clusters) can be manufactured on a single chip. Furthermore, after two different SiNW clusters are modified with Pb(2+)-selective and Cu(2+)-selective oligopeptide, respectively, concentrations of Pb(2+) and Cu(2+) in aqueous solutions can be detected simultaneously and selectively in two different channels. By using the SiNW arrays, we successfully achieved a detection limit of 1 nM for Pb(2+) and 10 nM for Cu(2+), respectively. These results demonstrate the potential utility of oligopeptide-modified SiNW arrays for highly sensitive and selective chemical and biological sensing applications.
- Subjects :
- Adsorption
Equipment Design
Equipment Failure Analysis
Ions
Metals chemistry
Microelectrodes
Nanotubes ultrastructure
Protein Binding
Transducers
Biosensing Techniques instrumentation
Electrochemistry instrumentation
Metals analysis
Microarray Analysis instrumentation
Nanotubes chemistry
Oligopeptides chemistry
Silicon chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4235
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Biosensors & bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 19443202
- Full Text :
- https://doi.org/10.1016/j.bios.2009.04.007