Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group.

Authors :: Speranza A
Ortosecco G
Castaldi E
Nardelli A
Pace L
Salvatore M
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2009 Sep; Vol. 67 (9), pp. 1664-9. Date of Electronic Publication: 2009 Apr 22.
Publication Year :: 2009
Abstract: Automatic synthesis of 4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlab FX(F-N) synthesis module to be used as prosthetic group for amino-oxy functionalized peptide labelling in clinical routine application. In addition a handmade purification device (HPD) has been setup to perform automatic cartridge purification as well as to back-up the reactor where one-pot synthesis is not applicable. Cartridges for solid phase extraction such as C18, C8, phenyl has been tested to best perform purification as well as activity recovery. Radiochemical yield (RCY) at end of synthesis (EOS) was in average 67% after about 45 min (90% decay corrected at EOB). The RCY of the entire procedure was 54% with a radiochemical purity above 99%.

Subjects :: Fluorine Radioisotopes
Isotope Labeling
Benzaldehydes chemistry
Peptides chemistry
Radiopharmaceuticals chemistry

Language :: English
ISSN :: 1872-9800
Volume :: 67
Issue :: 9
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 19443231
Full Text :: https://doi.org/10.1016/j.apradiso.2009.04.008

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