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A case of acute promyelocytic leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans retinoic acid and chemotherapy.
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2009 May; Vol. 36 (5), pp. 827-30. - Publication Year :
- 2009
-
Abstract
- A patient with acute promyelocytic leukemia(APL)treated with all-trans retinoic acid(ATRA)and chemotherapy for remission induction developed marked thrombocytosis after bone marrow recovery. Thrombocytosis also occurred after post remission chemotherapies, although the degree of thrombocytosis gradually decreased. During thrombocytosis, plasma levels of interleukin-6(IL-6)were elevated while those of thrombopoietin(TPO)were not elevated. However, the plasma level of TPO was markedly elevated at the nadir after post remission chemotherapy. These findings suggest that in APL patients, thrombocytosis after treatment with ATRA and or chemotherapy may be caused by increased plasma levels of both of IL-6 and TPO.
- Subjects :
- Humans
Leukemia, Promyelocytic, Acute blood
Leukemia, Promyelocytic, Acute complications
Male
Middle Aged
Thrombocytosis blood
Thrombocytosis complications
Antineoplastic Agents therapeutic use
Interleukin-6 blood
Leukemia, Promyelocytic, Acute drug therapy
Thrombocytosis drug therapy
Thrombopoietin blood
Tretinoin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0385-0684
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 19461187