GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

Authors :: Jasinska-Myga B
Wider C
Opala G
Krygowska-Wajs A
Barcikowska M
Czyzewski K
Baker M
Rademakers R
Uitti RJ
Farrer MJ
Ross OA
Wszolek ZK
Source :: European journal of neurology [Eur J Neurol] 2009 Aug; Vol. 16 (8), pp. 909-11. Date of Electronic Publication: 2009 Mar 31.
Publication Year :: 2009
Abstract: Background and Purpose: A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN.<br />Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland.<br />Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis).<br />Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.