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Metformin for obesity in children and adolescents: a systematic review.
- Source :
-
Diabetes care [Diabetes Care] 2009 Sep; Vol. 32 (9), pp. 1743-5. Date of Electronic Publication: 2009 Jun 05. - Publication Year :
- 2009
-
Abstract
- Objective: To summarize the efficacy of metformin in reducing BMI and cardiometabolic risk in obese children and adolescents without diabetes.<br />Research Design and Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs). Double-blind RCTs of > or =6 months duration in obese subjects age < or =19 years without diabetes were included. Our primary outcomes of interest include changes in BMI and measures of insulin sensitivity.<br />Results: Five trials met inclusion criteria (n = 320 individuals). Compared with placebo, metformin reduced BMI by 1.42 kg/m(2) (95% CI 0.83-2.02) and homeostasis model assessment insulin of resistance (HOMA-IR) score by 2.01 (95% CI 0.75-3.26).<br />Conclusions: Metformin appears to be moderately efficacious in reducing BMI and insulin resistance in hyperinsulinemic obese children and adolescents in the short term. Larger, longer-term studies in different populations are needed to establish its role in the treatment of overweight children.
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 19502540
- Full Text :
- https://doi.org/10.2337/dc09-0258