Back to Search
Start Over
Cardiac dysfunction after renal transplantation; incomplete resolution in pediatric population.
- Source :
-
Transplantation [Transplantation] 2009 Jun 15; Vol. 87 (11), pp. 1737-43. - Publication Year :
- 2009
-
Abstract
- Background: Long-term data of cardiac function after renal transplantation (RT) are limited, especially in children. Thus, we evaluated the status of left ventricular hypertrophy and various indices of left ventricular (LV) function in pediatric RT patients.<br />Methods: Blood pressure, serum biochemical profiles, electrocardiogram, and echocardiogram of 32 pediatric patients (mean age, 15.5+/-4.4 years) who underwent RT 5.1+/-2.5 years before and 29 body surface area-matched control subjects were studied.<br />Results: Repolarization abnormalities shown on electrocardiogram of pre-RT patients improved significantly after RT (QTc dispersion 50.8+/-37.3 to 37.4+/-11.9 msec, P=0.009). Left ventricular hypertrophy with increased LV mass index of pre-RT patients regressed remarkably after RT (LV mass index 120.9+/-40.5 to 69.2+/-14.5 g/m2, P<0.001); still, LV mass was significantly higher in RT patients than the controls (54.0+/-9.6 g/m2, P<0.001). Compared with the controls, the RT patients showed diastolic dysfunction (lower E/A ratio and higher isovolumic relaxation time) and lower myocardial performance (higher LV Tei index and weaker strain pattern). Patients who had shorter duration of non-RT renal replacement therapy showed better LV function (lower LV Tei index and stronger strain pattern) in the long-term follow-up.<br />Conclusions: Because cardiac dysfunction did not resolve after RT in pediatric population, regular evaluation for cardiovascular function after RT is required. Early RT may also be beneficial to global LV performance after RT.
- Subjects :
- Adolescent
Blood Pressure
Child
Diastole
Electrocardiography
Female
Heart Rate
Humans
Kidney Function Tests
Kidney Transplantation statistics & numerical data
Korea epidemiology
Male
Reoperation statistics & numerical data
Retrospective Studies
Systole
Ventricular Function, Left physiology
Young Adult
Heart Diseases epidemiology
Hypertension epidemiology
Kidney Transplantation physiology
Postoperative Complications epidemiology
Ventricular Dysfunction, Left epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6080
- Volume :
- 87
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 19502969
- Full Text :
- https://doi.org/10.1097/TP.0b013e3181a63f2f