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A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2009 Jun 14; Vol. 15 (22), pp. 2782-6. - Publication Year :
- 2009
-
Abstract
- Aim: To examine whether a dose-up to 900 mg of ursodeoxycholic acid (UDCA) decreases transaminases in hepatitis C patients.<br />Methods: From January to December 2007, patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus (HCV) (43-80 years old) showing positive serum HCV-RNA who had already taken 600 mg/d of UDCA were recruited into this study. Blood parameters were examined at 4, 8 and 24 wk after increasing the dose of oral UDCA from 600 to 900 mg/d.<br />Results: Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) levels were significantly decreased following the administration of 900 mg/d as compared to 600 mg/d. The decrease in ALT from immediately before the dose-up of UDCA to 8 wk after the dose-up was 14.3 IU/L, while that for AST was 10.5 IU/L and for GGT was 9.8 IU/L. Platelet count tended to increase after the dose-up of UDCA, although it did not show a statistically significant level (P = 0.05). Minor adverse events were observed in 3 cases, although no drop-outs from the study occurred.<br />Conclusion: Oral administration of 900 mg/d of UDCA was more effective than 600 mg/d for reducing ALT, AST, and GGT levels in patients with HCV-related chronic liver disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Animals
Bilirubin metabolism
Blood Platelets metabolism
Dose-Response Relationship, Drug
Female
Hepacivirus metabolism
Hepatitis C blood
Humans
Male
Middle Aged
Serum Albumin metabolism
Alanine Transaminase blood
Aspartate Aminotransferases blood
Hepatitis C drug therapy
Hepatitis C enzymology
Ursodeoxycholic Acid administration & dosage
Ursodeoxycholic Acid therapeutic use
gamma-Glutamyltransferase blood
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 15
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 19522030
- Full Text :
- https://doi.org/10.3748/wjg.15.2782