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New insights into granin-derived peptides: evolution and endocrine roles.
- Source :
-
General and comparative endocrinology [Gen Comp Endocrinol] 2009 Nov-Dec; Vol. 164 (2-3), pp. 161-74. Date of Electronic Publication: 2009 Jan 31. - Publication Year :
- 2009
-
Abstract
- The granin protein family is composed of two chromogranin and five secretogranin members that are acidic, heat-stable proteins in secretory granules in cells of the nervous and endocrine systems. We report that there is little evidence for evolutionary relationships among the granins except for the chromogranin group. The main granin members, including chromogranin A and B, and secretogranin II are moderately conserved in the vertebrates. Several small bioactive peptides can be generated by proteolysis from those homologous domains existing within the granin precursors, reflecting the conservation of biological activities in different vertebrates. In this context, we focus on reviewing the distribution and function of the major granin-derived peptides, including vasostatin, bovine CgB(1-41) and secretoneurin in vertebrate endocrine systems, especially those associated with growth, glucose metabolism and reproduction.
- Subjects :
- Amino Acid Sequence
Animals
Chromogranins chemistry
Chromogranins genetics
Endocrine System metabolism
Humans
Molecular Sequence Data
Neuropeptides chemistry
Neuropeptides genetics
Neuropeptides metabolism
Peptide Hormones chemistry
Peptide Hormones genetics
Peptide Hormones metabolism
Phylogeny
Sequence Homology, Amino Acid
Chromogranins physiology
Endocrine System physiology
Evolution, Molecular
Neuropeptides physiology
Peptide Hormones physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6840
- Volume :
- 164
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- General and comparative endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 19523383
- Full Text :
- https://doi.org/10.1016/j.ygcen.2009.01.011