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Orthodontic mechanotransduction and the role of the P2X7 receptor.
- Source :
-
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics [Am J Orthod Dentofacial Orthop] 2009 Jun; Vol. 135 (6), pp. 694.e1-16; discussion 694-5. - Publication Year :
- 2009
-
Abstract
- Introduction: The P2X7 receptor plays a crucial role in bone biology and inflammation. Its main function is to promote necrotic tissue metabolism by ensuring a normal acute-phase inflammatory response. We used a mouse model to describe and compare orthodontic mechanotransduction in wild-type and P2X7 knock-out mice.<br />Methods: By using finite element analysis, mouse orthodontic mechanics were scaled to produce typical human stress levels. External root resorption, bone modeling, and bone remodeling were analyzed with fluorescent bone labels, Masson trichrome stain, and microcomputed tomography. Relationships between the biologic responses and the calculated stresses were statistically tested and compared between mouse types.<br />Results: There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in the 2 types of mice.<br />Conclusions: Orthodontic responses are related to the principal stress patterns in the periodontal ligament, and the P2X7 receptor plays a significant role in their mechanotransduction.
- Subjects :
- Animals
Bone Density physiology
Bone Remodeling physiology
Bone Resorption pathology
Bone Resorption physiopathology
Coloring Agents
Computer-Aided Design
Disease Models, Animal
Finite Element Analysis
Fluorescent Dyes
Humans
Hyalin physiology
Imaging, Three-Dimensional
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Orthodontic Wires
Osteogenesis physiology
Periodontal Ligament pathology
Periodontal Ligament physiopathology
Random Allocation
Receptors, Purinergic P2X7
Root Resorption etiology
Root Resorption pathology
Single-Blind Method
Stress, Mechanical
Tooth Movement Techniques instrumentation
X-Ray Microtomography
Mechanotransduction, Cellular physiology
Receptors, Purinergic P2 physiology
Tooth Movement Techniques methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6752
- Volume :
- 135
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
- Publication Type :
- Academic Journal
- Accession number :
- 19524819
- Full Text :
- https://doi.org/10.1016/j.ajodo.2008.10.018