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[Tumoral angiogenesis: models, targets and inhibition].
- Source :
-
Journal de la Societe de biologie [J Soc Biol] 2009; Vol. 203 (2), pp. 167-70. Date of Electronic Publication: 2009 Jun 16. - Publication Year :
- 2009
-
Abstract
- Angiogenesis is a basic process during development and in pathology as well. The molecular networks involved in angiogenesis are not totally understood. We have recently developed a new model for tumoral angiogenesis in the chicken embryo, which allows large scale studies. On the other hand we have uncovered a new induction pathway, which involves stress of the endoplasmic reticulum. These investigations open up novel prospects for the future.
- Subjects :
- Angiogenesis Inhibitors pharmacology
Angiogenesis Inhibitors therapeutic use
Animals
Cell Hypoxia genetics
Chick Embryo
Gene Expression Regulation, Developmental
Humans
Hypoxia-Inducible Factor 1, alpha Subunit physiology
Unfolded Protein Response drug effects
Unfolded Protein Response physiology
Chorioallantoic Membrane blood supply
Endoplasmic Reticulum physiology
Neoplasms blood supply
Neovascularization, Pathologic drug therapy
Neovascularization, Pathologic genetics
Neovascularization, Pathologic physiopathology
Neovascularization, Physiologic genetics
Subjects
Details
- Language :
- French
- ISSN :
- 1295-0661
- Volume :
- 203
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal de la Societe de biologie
- Publication Type :
- Academic Journal
- Accession number :
- 19527630
- Full Text :
- https://doi.org/10.1051/jbio/2009020