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Estrone derived steroidal diepoxide: biologically active compound and precursor of a stable steroidal A,B-spiro system.

Authors :
Milic D
Kop T
Csanadi J
Juranic Z
Zizak Z
Gasic MJ
Solaja B
Source :
Steroids [Steroids] 2009 Nov; Vol. 74 (12), pp. 890-5. Date of Electronic Publication: 2009 Jun 16.
Publication Year :
2009

Abstract

A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac(2)O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented.

Details

Language :
English
ISSN :
1878-5867
Volume :
74
Issue :
12
Database :
MEDLINE
Journal :
Steroids
Publication Type :
Academic Journal
Accession number :
19538979
Full Text :
https://doi.org/10.1016/j.steroids.2009.06.002